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Adezmapimod (hydrochloride) [CAS 869185-85-3]

Adezmapimod (hydrochloride) [CAS 869185-85-3]

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QM-0081899-01

£68.47 GBP
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Product Details

  • Description

    Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator[1].

  • CAS Number

    [869185-85-3]

  • Molecular Formula

    C21H17ClFN3OS

  • Molecular Weight

    413.9

  • Smiles

    O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C.[H]Cl

  • Target

    Autophagy; Mitophagy; Organoid; p38 MAPK

  • Isoform

    P38 MAPK; p38β

  • Concentration

    10mM

  • Purity

    99.71

  • Solubility

    DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

  • Storage Conditions

    4°C (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302

  • Precautions

    H302
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Variant Variant total Quantity Price Variant total
5 mgQM-0081899-01
5 mgQM-0081899-01
£68.47/ea		 £0.00
£68.47/ea £0.00
10 mM - 1 mLQM-0081899-02
10 mM - 1 mLQM-0081899-02
£72.61/ea		 £0.00
£72.61/ea £0.00
10 mgQM-0081899-03
10 mgQM-0081899-03
£101.50/ea		 £0.00
£101.50/ea £0.00
50 mgQM-0081899-04
50 mgQM-0081899-04
£148.75/ea		 £0.00
£148.75/ea £0.00
100 mgQM-0081899-05
100 mgQM-0081899-05
£248.04/ea		 £0.00
£248.04/ea £0.00
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Adezmapimod (hydrochloride) [CAS 869185-85-3]

Adezmapimod (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.