Adezmapimod (hydrochloride) (Standard) [CAS 869185-85-3]
Adezmapimod (hydrochloride) (Standard) [CAS 869185-85-3]
SKU:QM-0002557-01
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Product Details
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Description
Adezmapimod (hydrochloride) (Standard) is the analytical standard of Adezmapimod (hydrochloride) . This product is intended for research and analytical applications. Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator[1].
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CAS Number
[869185-85-3]
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Molecular Formula
C21H17ClFN3OS
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Molecular Weight
413.9
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Smiles
O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C.[H]Cl
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Target
Autophagy; Mitophagy; Organoid; p38 MAPK; Reference Standards
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Shipping Conditions
Room temperature
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Adezmapimod (hydrochloride) (Standard) [CAS 869185-85-3]
Adezmapimod (hydrochloride) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.