Afatinib (Standard) [CAS 850140-72-6]
Afatinib (Standard) [CAS 850140-72-6]
SKU:QM-0081912-01
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Product Details
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Description
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].
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CAS Number
[850140-72-6]
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Molecular Formula
C24H25ClFN5O3
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Molecular Weight
485.94
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Smiles
O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C
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Target
Akt; Apoptosis; Autophagy; c-Met/HGFR; EGFR; p38 MAPK; Reference Standards
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Purity
97.64
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Storage Conditions
-20°C, sealed storage, away from light and moisture
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H319, H373, H402
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Precautions
H302, H319, H373, H402
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Afatinib (Standard) [CAS 850140-72-6]
Afatinib (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.