AKT-IN-3 [CAS 2374740-21-1]
AKT-IN-3 [CAS 2374740-21-1]
SKU:QM-0141813-01
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Product Details
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Description
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells[1].
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CAS Number
[2374740-21-1]
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Molecular Formula
C23H23Cl2F2N5O3
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Molecular Weight
526.36
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Smiles
CNC(C[C@H]1NC[C@@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[C@H](C4=CC(F)=C(F)C=C4)C1)=O
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Target
Akt; Apoptosis
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Isoform
Akt1; Akt2; Akt3
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Purity
98.12
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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AKT-IN-3 [CAS 2374740-21-1]
AKT-IN-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.