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Akt1-IN-8 [CAS 2247688-87-3]
Akt1-IN-8 [CAS 2247688-87-3]
SKU:QM-0011233
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Product Details
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Description
Akt1-IN-8 (Compound JL18) is a potent and oral bioavailable (41%) inhibitor of AKT1 kinase, with an IC50 of 8.8 nM. Akt1-IN-8 exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 can reduce phosphorylated GSK3β levels[1].
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CAS Number
[2247688-87-3]
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Molecular Formula
C21H25Br2N7O
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Molecular Weight
551.28
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Smiles
O=C(C(CNC(C)C)C1=CC=C(C=C1)Br)N2CCN(CC2)C3=C4C(Br)=NNC4=NC=N3
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Target
Akt
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Isoform
Akt1
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Shipping Conditions
Room temperature
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Akt1-IN-8 [CAS 2247688-87-3]
Akt1-IN-8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.