Alisertib (Standard) [CAS 1028486-01-2]
Alisertib (Standard) [CAS 1028486-01-2]
SKU:QM-0003570-01
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Product Details
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Description
Alisertib (Standard) is the analytical standard of Alisertib. This product is intended for research and analytical applications. Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3].
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CAS Number
[1028486-01-2]
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Molecular Formula
C27H20ClFN4O4
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Molecular Weight
518.92
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Smiles
O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O
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Target
Apoptosis; Aurora Kinase; Autophagy; Reference Standards
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Shipping Conditions
Room temperature
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Alisertib (Standard) [CAS 1028486-01-2]
Alisertib (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.