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ALK/EGFR-IN-1 [CAS 2730430-08-5]
ALK/EGFR-IN-1 [CAS 2730430-08-5]
SKU:QM-0071642
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Product Details
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Description
ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].
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CAS Number
[2730430-08-5]
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Molecular Formula
C27H34ClN7O3S
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Molecular Weight
572.12
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Smiles
O=S(CC)C1=C(NC2=NC(NC3=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C3)=NC=C2Cl)C=CC=C1
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Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; EGFR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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ALK/EGFR-IN-1 [CAS 2730430-08-5]
ALK/EGFR-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.