Almonertinib (hydrochloride) [CAS 2134096-03-8]
Almonertinib (hydrochloride) [CAS 2134096-03-8]
SKU:QM-0137724-01
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Product Details
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Description
Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM) . Almonertinib hydrochloride is used for the research of the non-small cell lung cancer[1][2].
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CAS Number
[2134096-03-8]
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Molecular Formula
C30H36ClN7O2
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Molecular Weight
562.11
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Smiles
COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.[H]Cl
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1
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Purity
98.92
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Solubility
DMSO : 5 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H317, H319, H335
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Precautions
H315, H317, H319, H335
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Almonertinib (hydrochloride) [CAS 2134096-03-8]
Almonertinib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.