Almonertinib (mesylate) [CAS 2134096-06-1]
Almonertinib (mesylate) [CAS 2134096-06-1]
SKU:QM-0137723-01
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Product Details
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Description
Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM) . Almonertinib mesylate is used for the research of the non-small cell lung cancer[1][2].
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CAS Number
[2134096-06-1]
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Molecular Formula
C31H39N7O5S
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Molecular Weight
621.75
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Smiles
COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.CS(=O)(O)=O
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Target
EGFR
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Purity
99.67
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Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Almonertinib (mesylate) [CAS 2134096-06-1]
Almonertinib (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.