Anagrelide (hydrochloride) [CAS 58579-51-4]
Anagrelide (hydrochloride) [CAS 58579-51-4]
SKU:QM-0158519-01
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Product Details
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Description
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM) . Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
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CAS Number
[58579-51-4]
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Molecular Formula
C10H8Cl3N3O
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Molecular Weight
292.55
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Smiles
ClC1=C(CN(C2)C3=NC2=O)C(N3)=CC=C1Cl.Cl
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Target
Apoptosis; Phosphodiesterase (PDE)
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Purity
99.39
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Solubility
DMSO : 6.36 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Anagrelide (hydrochloride) [CAS 58579-51-4]
Anagrelide (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.