Anemarsaponin B [CAS 139051-27-7]
Anemarsaponin B [CAS 139051-27-7]
SKU:QM-0163273-01
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Product Details
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Description
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3) . Anti-inflammatory effect [1].
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CAS Number
[139051-27-7]
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Molecular Formula
C45H74O18
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Molecular Weight
903.06
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Smiles
OC1C(CO)OC(OC2CCC(C(CCC3(C)C4CC5C3C(C)=C(CCC(COC6OC(CO)C(O)C(O)C6O)C)O5)C4CC7)(C)C7C2)C(OC8OC(CO)C(O)C(O)C8O)C1O
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Target
COX; MEK; NF-κB; NO Synthase
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Isoform
COX-2; iNOS; RelA/p65
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Anemarsaponin B [CAS 139051-27-7]
Anemarsaponin B is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.