Angelic acid [CAS 565-63-9]
Angelic acid [CAS 565-63-9]
SKU:QM-0205450-01
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Product Details
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Description
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity[1][2].
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CAS Number
[565-63-9]
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Molecular Formula
C5H8O2
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Molecular Weight
100.12
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Smiles
C/C=C(C)\C(O)=O
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Target
Ferroptosis; Keap1-Nrf2; Reactive Oxygen Species (ROS)
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Purity
99.2
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Solubility
DMSO : 200 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H290, H314
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Precautions
H290, H314
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Angelic acid [CAS 565-63-9]
Angelic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.