Anti-inflammatory agent 79 [CAS 9007-83-4]
Anti-inflammatory agent 79 [CAS 9007-83-4]
SKU:QM-0131868
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Product Details
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Description
Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body[1].
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CAS Number
[9007-83-4]
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Molecular Formula
C21H17NO2
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Molecular Weight
315.37
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Smiles
O=C(C1=CC=C(C2=COC=C2)C=C1C=C3)N3CCC4=CC=CC=C4
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Target
HIF/HIF Prolyl-Hydroxylase
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Isoform
HIF-1α
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Anti-inflammatory agent 79 [CAS 9007-83-4]
Anti-inflammatory agent 79 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.