Anticancer agent 65 [CAS 2407861-48-5]
Anticancer agent 65 [CAS 2407861-48-5]
SKU:QM-0066600
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Product Details
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Description
Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].
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CAS Number
[2407861-48-5]
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Molecular Formula
C36H63NO5
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Molecular Weight
589.89
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Smiles
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
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Target
Apoptosis; Bcl-2 Family; MDM-2/p53; MMP; Reactive Oxygen Species (ROS)
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Isoform
Bax; Bcl-2; MMP
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Anticancer agent 65 [CAS 2407861-48-5]
Anticancer agent 65 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.