Antitumor agent-172 [CAS 3027905-74-1]
Antitumor agent-172 [CAS 3027905-74-1]
SKU:QM-0153610-01
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Product Details
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Description
Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with Kd of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].
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CAS Number
[3027905-74-1]
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Molecular Formula
C37H50N8O4
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Molecular Weight
670.84
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Smiles
O=C(C(C)(OC1=CC(N2CCC[C@H](C2)NC(N(CC3=CC=C(C=C3)C4=CNN=C4)C5CC5)=O)=CC=C1)C)NCC(N6CCCC6CCN)=O
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Target
β-catenin
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Purity
98.51
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Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Antitumor agent-172 [CAS 3027905-74-1]
Antitumor agent-172 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.