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Antitumor agent-177 [CAS 9007-83-4]
Antitumor agent-177 [CAS 9007-83-4]
SKU:QM-0110542
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Product Details
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Description
Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo[1].
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CAS Number
[9007-83-4]
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Molecular Formula
C28H21F7O4
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Molecular Weight
554.45
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Smiles
OC(C1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(COC4=CC=C(F)C=C4)=C1)CC(O)(C(F)(F)F)C(F)(F)F
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Target
FGFR
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Isoform
FGFR
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Shipping Conditions
Room temperature
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Antitumor agent-177 [CAS 9007-83-4]
Antitumor agent-177 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.