Antitumor agent-195
Antitumor agent-195
SKU:QM-0009730
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Product Details
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Description
Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model[1].
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Molecular Formula
C22H22N2O4
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Molecular Weight
378.42
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Smiles
O=C(C1=C(C2=C3C4=C(C(N(CCN5CCCCC5)CC4)=O)O2)C=CC=C1)C3=O
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Target
Quinone Reductase; STAT
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Isoform
NQO1; STAT3
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Shipping Conditions
Room temperature
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Antitumor agent-195
Antitumor agent-195 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.