Antitumor photosensitizer-5 [CAS 9007-83-4]
Antitumor photosensitizer-5 [CAS 9007-83-4]
SKU:QM-0073580
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Product Details
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Description
Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC50 of 0.3 μM for phototoxicity to A549 cells. Under 460 nm light irradiation, antitumor photosensitizer-5 induces the generation of reactive oxygen species and NADH depletion, causes mitochondrial damage and activation of caspase-3, inducing apoptosis and suppressing cell migration. Antitumor photosensitizer-5 has the potential to prevent the growth of malignant tumors, therefore, shows the potential to be applied to photodynamic therapy[1].
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CAS Number
[9007-83-4]
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Molecular Formula
C53H43F12N11O2P2RuS
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Molecular Weight
1289.04
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Smiles
O=C(CCCCC1SCC2NC(NC21)=O)NC3=CC=C(C(N4)=NC5=C4C(C=CC=[N]67)=C6C8=C5C=CC=[N]8[Ru+2]9%107([N]%11=C%12C(C=CC%13=C%12[N]%10=CC=C%13)=CC=C%11)[N]%14=CC=CC%15=C%14C%16=[N]9C=CC=C%16C=C%15)C=C3.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Target
Apoptosis; Reactive Oxygen Species (ROS)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Antitumor photosensitizer-5 [CAS 9007-83-4]
Antitumor photosensitizer-5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.