AP14145 (hydrochloride) [CAS 2387505-59-9]
AP14145 (hydrochloride) [CAS 2387505-59-9]
SKU:QM-0059828
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Product Details
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Description
AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) [1][2].
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CAS Number
[2387505-59-9]
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Molecular Formula
C18H18ClF3N4O
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Molecular Weight
398.81
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Smiles
CC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O.[H]Cl
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Target
Potassium Channel
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Purity
98.3
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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AP14145 (hydrochloride) [CAS 2387505-59-9]
AP14145 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.