API-1 [CAS 36707-00-3]
API-1 [CAS 36707-00-3]
SKU:QM-0136662-01
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Product Details
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Description
API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM) . API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model[1][2][3].
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CAS Number
[36707-00-3]
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Molecular Formula
C13H15N5O6
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Molecular Weight
337.29
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Smiles
O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=NC=NC(N)=C3C(C(C(N)=O)=C2)=O
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Target
Akt; Apoptosis; Caspase; PARP
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Isoform
Caspase 3; Caspase 8; Caspase 9; PARP
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Purity
99.62
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301
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Precautions
H301
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API-1 [CAS 36707-00-3]
API-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.