USP7-IN-18 [CAS 3052223-40-9]
USP7-IN-18 [CAS 3052223-40-9]
SKU:QM-0011868
Request quote or documents
![USP7-IN-18 [CAS 3052223-40-9]](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
-
Description
USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions[1].
-
CAS Number
[3052223-40-9]
-
Molecular Formula
C30H28ClN3O3S
-
Molecular Weight
546.08
-
Smiles
CC1(C2C(N(C(C21)=O)CC3=CC4=C(C(C5=CC(Cl)=C6C=CC=CC6=C5OC7CCNCC7)=CC=N4)S3)=O)C
-
Target
Deubiquitinase; DNA Methyltransferase; MDM-2/p53
-
Shipping Conditions
Room temperature
Related Products
- QM-0011446-01 USP7 activator 1 [CAS 868940-26-5]
- QM-0010978 Vancomycin prodrug
- QM-0077398-01 USP7-797 [CAS 2413944-70-2]
- QM-0152977-01 USP7-IN-13 [CAS 2305046-93-7]
- QM-0146926-01 USP5-IN-1 [CAS 2851040-81-6]
- QM-0137353-01 USP7-IN-3 [CAS 2202738-42-7]
- QM-0149098-01 USP7-IN-9 [CAS 2444374-01-8]
- QM-0144869-01 USP7/USP47 inhibitor [CAS 1247825-37-1]
- QM-0077274-01 USP7-IN-10 (hydrochloride)
- QM-0154039-01 USP7-IN-1 [CAS 1381291-36-6]
Other industry favorites
- QM-0011446-01 USP7 activator 1 [CAS 868940-26-5]
- QM-0010978 Vancomycin prodrug
- QM-0046246 Usp48 Rat Pre-designed siRNA Set A
- QM-0045051 Usp6nl Rat Pre-designed siRNA Set A
- QM-0033533 Vensobafusp alfa [CAS 2724922-85-2]
- QM-0026904 USP7, Human (sf9, His)
USP7-IN-18 [CAS 3052223-40-9]
USP7-IN-18 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.