Apostatin-1 [CAS 2559703-06-7]
Apostatin-1 [CAS 2559703-06-7]
SKU:QM-0144621-01
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Product Details
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Description
Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1].
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CAS Number
[2559703-06-7]
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Molecular Formula
C19H27N3OS
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Molecular Weight
345.5
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Smiles
O=C(NC1CCCCCC1)C(SC2=NCCN2C)C3=CC=CC=C3
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Target
Apoptosis; Autophagy; Beclin1; Necroptosis; RIP kinase
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Isoform
RIPK1
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Purity
99.84
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Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 80°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Apostatin-1 [CAS 2559703-06-7]
Apostatin-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.