Apratastat [CAS 287405-51-0]
Apratastat [CAS 287405-51-0]
SKU:QM-0139573-01
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Product Details
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Description
Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of TNF-α. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC) [1][2]. Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[287405-51-0]
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Molecular Formula
C17H22N2O6S2
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Molecular Weight
414.5
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Smiles
CC1(C)[C@H](C(NO)=O)N(S(=O)(C2=CC=C(OCC#CCO)C=C2)=O)CCS1
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Target
MMP; TNF Receptor
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Isoform
TNFRSF5/CD40
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Purity
99.29
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Apratastat [CAS 287405-51-0]
Apratastat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.