Aprindine (hydrochloride) [CAS 33237-74-0]
Aprindine (hydrochloride) [CAS 33237-74-0]
SKU:QM-0157316-01
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Product Details
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Description
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias[1][2][3][4].
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CAS Number
[33237-74-0]
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Molecular Formula
C22H31ClN2
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Molecular Weight
358.95
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Smiles
CCN(CC)CCCN(C1CC2=C(C=CC=C2)C1)C3=CC=CC=C3.[H]Cl
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Target
Calcium Channel; Calmodulin; Potassium Channel; Sodium Channel
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Concentration
10mM
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Purity
98.96
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Aprindine (hydrochloride) [CAS 33237-74-0]
Aprindine (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.