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APS-2-79 (hydrochloride) [CAS 2002381-31-7]
APS-2-79 (hydrochloride) [CAS 2002381-31-7]
SKU:QM-0000093-01
£78.82 GBP
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![APS-2-79 (hydrochloride) [CAS 2002381-31-7]](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
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Description
APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
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CAS Number
[2002381-31-7]
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Molecular Formula
C23H22ClN3O3
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Molecular Weight
423.89
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Smiles
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.Cl
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Target
MEK
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Isoform
MEK1
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Purity
98.42
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Solubility
DMSO : 25 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H361, H372, H410
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Precautions
H302, H361, H372, H410
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APS-2-79 (hydrochloride) [CAS 2002381-31-7]
APS-2-79 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.