Araguspongin B [CAS 123000-02-2]
Araguspongin B [CAS 123000-02-2]
SKU:QM-0100884-01
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Product Details
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Description
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
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CAS Number
[123000-02-2]
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Molecular Formula
C29H52N2O
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Molecular Weight
444.74
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Smiles
[H][C@@]1(CCC2)[C@]3([H])N2CC[C@@](CCCCCC[C@@]4([H])[C@@]5([H])O[C@@](CCN5CCC4)([H])CCCCCC1)([H])C3
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Target
Calcium Channel
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Shipping Conditions
Room temperature
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Araguspongin B [CAS 123000-02-2]
Araguspongin B is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.