Articaine (hydrochloride) [CAS 23964-57-0]
Articaine (hydrochloride) [CAS 23964-57-0]
SKU:QM-0158497-01
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Product Details
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Description
Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) [1][2][3].
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CAS Number
[23964-57-0]
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Molecular Formula
C13H21ClN2O3S
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Molecular Weight
320.84
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Smiles
O=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O.Cl
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Target
NF-κB; NOD-like Receptor (NLR) ; Sodium Channel
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Isoform
NLRP3
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Concentration
10mM
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Purity
99.38
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H335
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Precautions
H315, H319, H335
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Articaine (hydrochloride) [CAS 23964-57-0]
Articaine (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.