Atabecestat [CAS 1200493-78-2]
Atabecestat [CAS 1200493-78-2]
SKU:QM-0136372-01
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Product Details
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Description
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat s tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat has the potential for Alzheimer's Disease treatment[1].
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CAS Number
[1200493-78-2]
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Molecular Formula
C18H14FN5OS
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Molecular Weight
367.4
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Smiles
O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)SC=C3)=C2
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Target
Beta-secretase
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Isoform
BACE1
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Concentration
10mM
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Purity
99.77
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H361-H373
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Precautions
P260-P280-P405-P501
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Atabecestat [CAS 1200493-78-2]
Atabecestat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.