Atiprimod (hydrochloride) [CAS 130065-61-1]
Atiprimod (hydrochloride) [CAS 130065-61-1]
SKU:QM-0058193
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Product Details
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Description
Atiprimod (Azaspirane) hydrochloride is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of JAK2 and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2α/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) [1][2][3][4][5][6].
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CAS Number
[130065-61-1]
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Molecular Formula
C22H46Cl2N2
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Molecular Weight
409.52
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Smiles
CCN(CCCN1CCC2(CCC(CCC)(CC2)CCC)C1)CC.Cl.Cl
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Target
Apoptosis; Atg8/LC3; Autophagy; Caspase; JAK; p62; Reactive Oxygen Species (ROS) ; STAT
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Atiprimod (hydrochloride) [CAS 130065-61-1]
Atiprimod (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.