Atopaxar (hydrochloride) [CAS 474544-83-7]
Atopaxar (hydrochloride) [CAS 474544-83-7]
SKU:QM-0122954
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Product Details
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Description
Atopaxar hydrochloride (E5555 hydrochloride) is the hydrochloride salt form of Atopaxar. Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 (PAR-1). Atopaxar hydrochloride is the inhibitor for Janus kinase 1 (JAK1) and JAK2, which inhibits the JAK-STAT with EC50 of 5.90 μM in A549. Atopaxar hydrochloride inhibits the cell viability of A549 (IC50=7.02 μM), arrests the cell cycle at G1 phase and induces apoptosis. Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease[1][2][3].
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CAS Number
[474544-83-7]
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Molecular Formula
C29H39ClFN3O5
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Molecular Weight
564.09
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Smiles
COC1=C(N2CCOCC2)C=C(C(CN(CC3=C4C(F)=C(OCC)C(OCC)=C3)C4=N)=O)C=C1C(C)(C)C.Cl
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Target
Apoptosis; JAK; Protease Activated Receptor (PAR)
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Isoform
PAR1
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Shipping Conditions
Room temperature
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Atopaxar (hydrochloride) [CAS 474544-83-7]
Atopaxar (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.