Auristatin E [CAS 160800-57-7]
Auristatin E [CAS 160800-57-7]
SKU:QM-0151798-01
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Product Details
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Description
Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 , is linear peptides comprised of four amino acids[1][2][3].
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CAS Number
[160800-57-7]
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Molecular Formula
C40H69N5O7
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Molecular Weight
732.01
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Smiles
CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O
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Target
ADC Payload; Microtubule/Tubulin
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Isoform
Auristatin
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Purity
99.89
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Room Temperature
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Hazard Statement
H341, H361, H372
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Precautions
H341, H361, H372
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Auristatin E [CAS 160800-57-7]
Auristatin E is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.