Auristatin E-d8
Auristatin E-d8
SKU:QM-0007663-01
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Product Details
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Description
Auristatin E-d8 is the deuterium labeled Auristatin E. Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids[1][2][3].
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Molecular Formula
C40H61D8N5O7
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Molecular Weight
740.05
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Smiles
CC(C)[C@H](N(C)C)C(NC(C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O
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Target
ADC Payload; Isotope-Labeled Compounds; Microtubule/Tubulin
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Purity
99.48
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Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Auristatin E-d8
Auristatin E-d8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.