Aurora kinase/HDAC-IN-1 [CAS 2727102-12-5]
Aurora kinase/HDAC-IN-1 [CAS 2727102-12-5]
SKU:QM-0015965
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Product Details
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Description
Aurora kinase/HDAC-IN-1 is an orally active dual Aurora kinase and HDAC inhibitor that inhibits Aurora A (IC50 = 116 nM), Aurora B (IC50 = 225 nM), HDAC1 (IC50 = 164 nM), and HDAC2 (IC50 = 346 nM) .Aurora kinase/HDAC-IN-1 promotes histone H3 acetylation, inhibits Aurora A phosphorylation and downstream signaling, and induces apoptosis via G2/M cell-cycle arrest. Aurora kinase/HDAC-IN-1 exhibits potent antiproliferative activity in colorectal cancer cells, with an IC50 value of 30.2 nM in HCT-116 cells.Aurora kinase/HDAC-IN-1 significantly suppresses tumor growth in an HCT-116 colorectal cancer xenograft mouse model[1].
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CAS Number
[2727102-12-5]
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Molecular Formula
C22H20FN7OS
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Molecular Weight
449.5
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Smiles
O=C(C1=CC=C(CSC2=NC=CC(NC3=NNC(C)=C3)=N2)C=C1)NC4=CC=C(C=C4N)F
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Target
Apoptosis; Aurora Kinase; HDAC
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Isoform
Aurora A; Aurora B; HDAC1; HDAC2
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Shipping Conditions
Room temperature
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Aurora kinase/HDAC-IN-1 [CAS 2727102-12-5]
Aurora kinase/HDAC-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.