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Avagacestat [CAS 1146699-66-2]

Avagacestat [CAS 1146699-66-2]

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QM-0156471-01

£108.25 GBP
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Product Details

  • Description

    Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research.

  • CAS Number

    [1146699-66-2]

  • Molecular Formula

    C20H17ClF4N4O4S

  • Molecular Weight

    520.89

  • Smiles

    O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O

  • Target

    Notch; γ-secretase

  • Purity

    99.92

  • Solubility

    DMSO : ≥ 100 mg/mL

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H315, H319, H335

  • Precautions

    H315, H319, H335
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Variant Variant total Quantity Price Variant total
1 mgQM-0156471-01
1 mgQM-0156471-01
£108.25/ea		 £0.00
£108.25/ea £0.00
5 mgQM-0156471-02
5 mgQM-0156471-02
£240.75/ea		 £0.00
£240.75/ea £0.00
10 mM - 1 mLQM-0156471-03
10 mM - 1 mLQM-0156471-03
£268.70/ea		 £0.00
£268.70/ea £0.00
10 mgQM-0156471-04
10 mgQM-0156471-04
£354.96/ea		 £0.00
£354.96/ea £0.00
25 mgQM-0156471-05
25 mgQM-0156471-05
£622.26/ea		 £0.00
£622.26/ea £0.00
50 mgQM-0156471-06
50 mgQM-0156471-06
£881.06/ea		 £0.00
£881.06/ea £0.00
100 mgQM-0156471-07
100 mgQM-0156471-07
£1,255.28/ea		 £0.00
£1,255.28/ea £0.00
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Avagacestat [CAS 1146699-66-2]

Avagacestat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.