Avagacestat (Standard) [CAS 1146699-66-2]
Avagacestat (Standard) [CAS 1146699-66-2]
SKU:QM-0017445-01
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Product Details
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Description
Avagacestat (Standard) is the analytical standard of Avagacestat. This product is intended for research and analytical applications. Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research.
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CAS Number
[1146699-66-2]
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Molecular Formula
C20H17ClF4N4O4S
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Molecular Weight
520.89
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Smiles
O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O
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Target
Notch; Reference Standards; γ-secretase
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Shipping Conditions
Room temperature
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Avagacestat (Standard) [CAS 1146699-66-2]
Avagacestat (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.