Avanafil-13C5
Avanafil-13C5
SKU:QM-0016435
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Product Details
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Description
Avanafil-13C5 (TA1790-13C5) is 13C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis[1][2][3].
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Molecular Formula
C18 13C5H21ClN7O3
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Molecular Weight
483.87
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Smiles
COC1=C(Cl)C=C(CNC2=C(C(N[13C][13C]3=N[13C]=[13C][13C]=N3)=O)C=NC(N4[C@H](CO)CCC4)=N2)C=C1
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Target
Endogenous Metabolite; Isotope-Labeled Compounds; NO Synthase; Phosphodiesterase (PDE)
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Shipping Conditions
Room temperature
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Avanafil-13C5
Avanafil-13C5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.