Avanafil-13C5,15N, d2
Avanafil-13C5,15N, d2
SKU:QM-0092710
Request quote or documents
Product Details
-
Description
Avanafil-13C5,15N, d2 is 15N and deuterated labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis[1][2][3].
-
Molecular Formula
C18 13C5H24D2ClN6 15NO3
-
Molecular Weight
491.92
-
Smiles
COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC([15N]4[13C@H]([13C]([2H])([2H])O)[13CH2][13CH2][13CH2]4)=N2)C=C1
-
Target
Endogenous Metabolite; Isotope-Labeled Compounds; NO Synthase; Phosphodiesterase (PDE)
-
Solubility
10 mM in DMSO
-
Shipping Conditions
Room temperature
Related Products
- QM-0162455-01 L-Methionine-13C, d3 [CAS 73488-65-0]
- QM-0054477-01 Zoledronic acid-15N2,13C2 [CAS 1189694-79-8]
- QM-0054003 δ-Hexachlorocyclohexane-13C6
- QM-0050094-01 Zopiclone impurity-1 [CAS 43200-81-3]
- QM-0026012 β-CL, Ala (13C3,15N) (TFA)
- QM-0025750-01 β-Amyloid (1-42), human, Ala (13C3,15N) (TFA)
- QM-0025699 YLYEIA- (Arg-13C6,15N4) (TFA)
- QM-0021653 β-Carotene-13C10 [CAS 301150-50-5]
- QM-0021627 β-Alanine-13C [CAS 65138-34-3]
- QM-0017969 Zonisamide-13C6
Other industry favorites
- QM-0162455-01 L-Methionine-13C, d3 [CAS 73488-65-0]
- QM-0054477-01 Zoledronic acid-15N2,13C2 [CAS 1189694-79-8]
- QM-0149176-01 β-lactosyl-13C
- QM-0162836-01 Xylose-2-13C [CAS 131771-69-2]
- QM-0081032 Zinc Protoporphyrin-d2,15N2
- QM-0096503 Zileuton-13C2,15N
- QM-0002345-01 γ-Glu- (Phe-13C9,15N) (TFA)
- QM-0162837-01 Xylose-5-13C [CAS 139657-63-9]
- QM-0060991 Yohimbine-13C, d3 [CAS 1261254-59-4]
- QM-0074149 β-D-Glucose pentaacetate-13C6 [CAS 213020-65-6]
Avanafil-13C5,15N, d2
Avanafil-13C5,15N, d2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.