AX-024 (hydrochloride) [CAS 1704801-24-0]
AX-024 (hydrochloride) [CAS 1704801-24-0]
SKU:QM-0112480-01
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Product Details
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Description
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
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CAS Number
[1704801-24-0]
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Molecular Formula
C21H23ClFNO2
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Molecular Weight
375.86
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Smiles
COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1.[H]Cl
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Target
IFNAR; Interleukin Related; TNF Receptor
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Isoform
IL-10; IL-17; IL-6; TNFRSF5/CD40
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Purity
99.23
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Solubility
DMSO : 33 mg/mL (ultrasonic; warming) |H2O : 16.67 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
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Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
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AX-024 (hydrochloride) [CAS 1704801-24-0]
AX-024 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.