Azimilide (dihydrochloride) [CAS 149888-94-8]
Azimilide (dihydrochloride) [CAS 149888-94-8]
SKU:QM-0155006-01
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Product Details
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Description
Azimilide (NE-10064) dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ) ) and IKr (IC50 = 1 μM (4 mM [K⁺]) ) . Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM) . Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation[1][2][3][4].
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CAS Number
[149888-94-8]
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Molecular Formula
C23H30Cl3N5O3
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Molecular Weight
530.88
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Smiles
O=C1N(CCCCN2CCN(C)CC2)C(CN1/N=C/C3=CC=C(C4=CC=C(Cl)C=C4)O3)=O.[H]Cl.[H]Cl
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Target
Calcium Channel; Potassium Channel; Sodium Channel
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Isoform
Inwardly rectifying potassium channel; L-type calcium channel
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Purity
98.17
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Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301
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Precautions
H301
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Azimilide (dihydrochloride) [CAS 149888-94-8]
Azimilide (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.