Bardoxolone (Standard) [CAS 218600-44-3]
Bardoxolone (Standard) [CAS 218600-44-3]
SKU:QM-0007305-01
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Product Details
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Description
Bardoxolone (Standard) is the analytical standard of Bardoxolone. This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury[1][2].
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CAS Number
[218600-44-3]
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Molecular Formula
C31H41NO4
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Molecular Weight
491.66
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Smiles
CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1
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Target
Keap1-Nrf2; Necroptosis; Reference Standards; SARS-CoV; Virus Protease
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Shipping Conditions
Room temperature
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Bardoxolone (Standard) [CAS 218600-44-3]
Bardoxolone (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.