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BAY 61-3606 (dihydrochloride) [CAS 648903-57-5]

BAY 61-3606 (dihydrochloride) [CAS 648903-57-5]

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QM-0150151-01

£244.40 GBP
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Product Details

  • Description

    BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM[1]. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4].

  • CAS Number

    [648903-57-5]

  • Molecular Formula

    C20H20Cl2N6O3

  • Molecular Weight

    463.32

  • Smiles

    O=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl

  • Target

    Apoptosis; Syk

  • Purity

    99.45

  • Solubility

    H2O : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)

  • Storage Conditions

    -20°C (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Blue Ice

  • Hazard Statement

    H315, H319, H320

  • Precautions

    H315, H319, H320
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Variant Variant total Quantity Price Variant total
5 mgQM-0150151-01
5 mgQM-0150151-01
£244.40/ea		 £0.00
£244.40/ea £0.00
10 mgQM-0150151-02
10 mgQM-0150151-02
£322.16/ea		 £0.00
£322.16/ea £0.00
25 mgQM-0150151-03
25 mgQM-0150151-03
£489.83/ea		 £0.00
£489.83/ea £0.00
50 mgQM-0150151-04
50 mgQM-0150151-04
£621.05/ea		 £0.00
£621.05/ea £0.00
100 mgQM-0150151-05
100 mgQM-0150151-05
£740.12/ea		 £0.00
£740.12/ea £0.00
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BAY 61-3606 (dihydrochloride) [CAS 648903-57-5]

BAY 61-3606 (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.