BChE/p38-α MAPK-IN-1 [CAS 3077831-11-6]
BChE/p38-α MAPK-IN-1 [CAS 3077831-11-6]
SKU:QM-0013322
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Product Details
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Description
BChE/p38-α MAPK-IN-1 is a selective dual inhibitor of hBChE (IC50 = 772 nM) and p38α MAPK (IC50 = 191 nM). BChE/p38-α MAPK-IN-1 reduces the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) in cells. BChE/p38-α MAPK-IN-1 improves Scopolamine -induced cognitive impairment, as well as alleviates LPS (HY-D1056) -induced spatial learning impairment and exerts anti-neuroinflammatory effects in mice. BChE/p38-α MAPK-IN-1 can be used for the study of Alzheimer’s disease (AD) by targeting both cholinergic deficit and neuroinflammation[1].
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CAS Number
[3077831-11-6]
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Molecular Formula
C26H32F2N4O
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Molecular Weight
454.56
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Smiles
O=C(C1=CC2=C(C=C1CC3=CC=C(F)C=C3F)C=NN2CC4CCCCC4)NCCN(C)C
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Target
Cholinesterase (ChE) ; Interleukin Related; p38 MAPK
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Isoform
BChE; p38α
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Shipping Conditions
Room temperature
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BChE/p38-α MAPK-IN-1 [CAS 3077831-11-6]
BChE/p38-α MAPK-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.