Bis-sulfone-PEG4-NHS ester [CAS 2055047-19-1]
Bis-sulfone-PEG4-NHS ester [CAS 2055047-19-1]
SKU:QM-0051282
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Product Details
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Description
Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
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CAS Number
[2055047-19-1]
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Molecular Formula
C40H48N2O14S2
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Molecular Weight
844.94
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Smiles
O=C(CCOCCOCCOCCOCCNC(C1=CC=C(C(C(CS(=O)(C2=CC=C(C)C=C2)=O)CS(=O)(C3=CC=C(C)C=C3)=O)=O)C=C1)=O)ON4C(CCC4=O)=O
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Target
Biochemical Assay Reagents
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Bis-sulfone-PEG4-NHS ester [CAS 2055047-19-1]
Bis-sulfone-PEG4-NHS ester is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.