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BMS-1166 (hydrochloride) [CAS 2113650-05-6]
BMS-1166 (hydrochloride) [CAS 2113650-05-6]
SKU:QM-0081740-01
£289.36 GBP
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Product Details
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Description
BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2].
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CAS Number
[2113650-05-6]
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Molecular Formula
C36H34Cl2N2O7
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Molecular Weight
677.57
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Smiles
O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1.Cl
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Target
PD-1/PD-L1
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Purity
99.95
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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BMS-1166 (hydrochloride) [CAS 2113650-05-6]
BMS-1166 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.