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BMS-1166-N-piperidine-CO-N-piperazine [CAS 2447066-14-8]
BMS-1166-N-piperidine-CO-N-piperazine [CAS 2447066-14-8]
SKU:QM-0061733
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Product Details
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Description
BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?. PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
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CAS Number
[2447066-14-8]
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Molecular Formula
C41H43ClN4O5
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Molecular Weight
707.26
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Smiles
O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)N7CCNCC7
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Target
Target Protein Ligand-Linker Conjugates
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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BMS-1166-N-piperidine-CO-N-piperazine [CAS 2447066-14-8]
BMS-1166-N-piperidine-CO-N-piperazine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.