BMS-1166-N-piperidine-COOH [CAS 2447066-00-2]
BMS-1166-N-piperidine-COOH [CAS 2447066-00-2]
SKU:QM-0143585-01
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Product Details
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Description
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2].
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CAS Number
[2447066-00-2]
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Molecular Formula
C37H35ClN2O6
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Molecular Weight
639.14
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Smiles
O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)O
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Target
Ligands for Target Protein for PROTAC
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Purity
97.18
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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BMS-1166-N-piperidine-COOH [CAS 2447066-00-2]
BMS-1166-N-piperidine-COOH is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.