Bortezomib-d8
Bortezomib-d8
SKU:QM-0081861-01
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Product Details
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Description
Bortezomib-d8 is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) [1][2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) [7].
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Molecular Formula
C19H17D8BN4O4
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Molecular Weight
392.29
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Smiles
OB([C@H](CC(C)C)NC(C(NC(C1=NC=CN=C1)=O)([2H])C([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)O
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Target
Apoptosis; Autophagy; Isotope-Labeled Compounds; NF-κB; Proteasome; TREM receptor
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Purity
98
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Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |Ethanol : 66.67mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Bortezomib-d8
Bortezomib-d8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.