Braftide [CAS 2411851-64-2]
Braftide [CAS 2411851-64-2]
SKU:QM-0190270-01
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Product Details
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Description
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research[1][2].
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CAS Number
[2411851-64-2]
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Molecular Formula
C57H94N16O13S
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Molecular Weight
1243.52
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Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
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Target
Raf
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Purity
99.68
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Braftide [CAS 2411851-64-2]
Braftide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.