BRAFV600E/ABL2-IN-1
BRAFV600E/ABL2-IN-1
SKU:QM-0015195
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Product Details
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Description
BRAFV600E/ABL2-IN-1 is a BRAFV600E (IC50 = 0.088 μM) /ABL2 (IC50 = 0.3 μM) dual inhibitor. BRAFV600E/ABL2-IN-1 can diminish P-glycoprotein expression. BRAFV600E/ABL2-IN-1 effectively inhibits p-CrkL (Abl2 signaling) and p-ERK1/2 (BRAFV600E pathway) in A375-R melanoma cells. BRAFV600E/ABL2-IN-1 causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases and G2/M phase. BRAFV600E/ABL2-IN-1 significantly increases the percentage of late apoptotic cells. BRAFV600E/ABL2-IN-1 can be used for the study of melanoma[1].
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Molecular Formula
C24H20BrClN4O3S
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Molecular Weight
559.86
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Smiles
O=C(N/N=C(C1=CC=C(Br)C=C1)\C)CN2C(C3=CC=C(S(=O)(C)=O)C=C3)=NC4=CC(Cl)=CC=C24
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Target
Apoptosis; Bcr-Abl; PERK; P-glycoprotein; Raf
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Isoform
B-Raf
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Shipping Conditions
Room temperature
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BRAFV600E/ABL2-IN-1
BRAFV600E/ABL2-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.