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BRAFV600E/JNK-IN-1
BRAFV600E/JNK-IN-1
SKU:QM-0011264
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Product Details
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Description
BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM and 0.009 μM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities[1].
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Molecular Formula
C24H25ClN6O3S
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Molecular Weight
513.01
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Smiles
OC1=CC(C2=NN(CC)C=C2C3=CC=NC(NCCCNS(=O)(C4=CC=C(Cl)C=C4)=O)=N3)=CC=C1
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Target
JNK; MEK; NO Synthase; PERK
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Shipping Conditions
Room temperature
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BRAFV600E/JNK-IN-1
BRAFV600E/JNK-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.